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When botulinum toxin is injected near a motor end plate, where a trigger point would develop, this reduces the motor nerves ability to drive a sustained taut band in the muscle. If muscle tissue is then exposed to the chemical, the muscle will contract and eventually fail.

A research team at The University of Nottingham has been working with the US government over the last decade to develop a new treatment for this terrible disease, and in recent months we have developed a new solution using stem cells – a group of cells known to regenerate in the absence of cell division.

Using new stem cell grafts, we have created a viable model system showing how botulinum toxin can be treated successfully after injury, while keeping the motor nerves active and the muscles strong.

Scientists in Manchester recently reported a similar result when they developed a treatment for Parkinson’s, a neurodegenerative disease that affects movement and feeling in the body.

The findings are described in a recent academic paper, ‘A novel approach using stem cells to combat botulism toxin-induced neuromuscular paralysis’.

The work was funded by the UK Department for International Development (DFID). With this money, Professor David Boulton is pioneering stem cell therapies for many diseases, which the National Institute for Health Research (NIHR) and the Medical Research Council (MRC) have contributed to.

The key breakthrough involved using engineered cells derived from embryonic stem cells called induced pluripotent stem cells (iPSCs). These cells have the capability of changing into any cell type in the body by taking on DNA from another cell.

It has long been known that embryonic stem cells can be used to grow any type of tissue (from a heart, liver, brain or cartilage to blood cells) in the lab. But the breakthrough in using iPSCs to create new muscle was even more remarkable.

The Nottingham researchers injected a tiny dose of the toxin in the muscles of the rats, leaving them to recover naturally over a month, which allowed them to track the development. The rats were then injected with the new, safe version with an implant of the injected muscle.

After two weeks of treatment, the rats had developed a permanent taut band in the muscles they were using to move.

After five months, their movement was normal. In 10 weeks, the muscle strength was almost identical to that of normal animals but the toxin had been removed. The remaining toxin was completely safe inside the muscle, eliminating the risk of botulinum neurotoxin becoming toxic if injected near a motor end plate.

Professor David Boulton: “The treatment in rats shows that a treatment for Botulism

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